Datta, Shuvo and Kumar Pal, Nishith and Kumar Nandy, Ashoke (2017) In vitro Antibacterial Activity of Bioactive Potent Compounds from Terminalia chebula against Some Common Human Pathogens. Pharmacology & Pharmacy, 08 (09). pp. 283-291. ISSN 2157-9423
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Abstract
Objective: Emergence of community-acquired infections due to multi drug resistant (MDR) common human pathogens have caused a great problem to clinicians and this directed us to search systematically for a different remedy with compounds particularly from plant origin. Methods: The antibacterial activity was evaluated using agar well diffusion assay method against some common gram positive and gram negative bacteria. Results: In vitro study with Terminalia chebula Retz. (Combretaceae) stem bark extracts, eight isolated triterpenoids and four triterpenoid derivatives were found to be effective against Bacillus subtilis, Staphylococcus aureus, Salmonella typhi, Pseudomonas aeruginosa and Escherichia coli. Conclusions: Pure compounds from T.chebula could be effectively used as antibacterial agents if it is possible to develop the molecules synthetically. At the same time crude extracts with specified active principles could also be used and/or introduced in Traditional Medicine/Complementary Alternative Medicine (TM/CAM) as antibacterial into National/International Health Systems as per the guideline of Ayurvedic formularies.
Item Type: | Article |
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Subjects: | Pacific Library > Chemical Science |
Depositing User: | Unnamed user with email support@pacificlibrary.org |
Date Deposited: | 25 Feb 2023 09:36 |
Last Modified: | 24 May 2024 07:05 |
URI: | http://editor.classicopenlibrary.com/id/eprint/809 |