1,3,4-Thiadiazole Derivatives as an Antimicrobial: An Update

Persistent and uncontrolled use of antibiotics results in development of bacterial resistant. The situation is getting worsen day by day and scientists are investigating thousands of potentially active drugs like molecule in laboratories around the world every day in search of effective antibiotics. During last decade considerable attention was given to five-member heterocyclic moieties while designing new antimicrobial agents. One of important heterocycle is five-membered 1,3,4-thiadiazole with unique bioisosteric properties displaying unusually wide spectrum of biological activities. This comprehensive review represent the recent 1,3,4-thiadiazole and its derivatives, which can be considered as potential antimicrobial agents in the period of 2015 and onwards. This review may help the medicinal chemists to develop new leads possessing 1,3,4-thiadiazole nucleus with higher efficacy and reduced side effects.