Comparison of Clinical and Biochemical Parameters of Patients with Guillain Barre Syndrome and Myasthenia Gravis: Retrospective Single Center Experience

Background: Guillain-Barré syndrome (GBS) and Miyastenia gravis (MG) are common neurological autoimmune diseases. With this study, we aimed to compare the patients’ complaints, clinical course and laboratory parameters of both diseases.
Methods: This study was carried out as a retrospective file scan. The study covers the dates between April 1, 2017, and April 20, 2020. The GBS and MG patients were compared in terms of sociodemographic characteristics, application complaints, clinical course, laboratory findings, treatments and outcomes.
Results: In this study, 51 patients from both groups were included. The mean age of GBS and MG patients was 52.1 ±19.4 and 43.6 ±15.8 years, respectively. Respiratory involvement of the patients was 23.5% in GBS and 17.6% in MG. When the treatments of the patients were compared, it was observed that 78.4% of GBS patients and 98% of MG received IVIG treatments. Only two patients from GBS group were found to be ex. When the laboratory results were compared, it was found that lactate, vitamin D, transferrin and total iron binding capacity results were lower in GBS patients, whereas, vitamin B12 and ferritin results were lower in MG patients and this difference was statistically significant (p <0.05).
Conclusion: The clinical presentation of GBS and MG is diverse and the prognosis can vary significantly among patients. Within the scope of the data obtained from the study, it was concluded that wide anamnesis and laboratory analyzes are necessary and useful for the differential diagnosis of these two diseases.